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Research Publications on "Sho-saiko-to" (1990-2001)
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<59> Authors
Sakamoto S. Muroi N.
Matsuda M. Tajima M.
Kudo H. Kasahara N.
Suzuki S.
Sugiura Y. Kuwa K.
Namiki H. et al. Institution
Medical Research Institute, Tokyo Medical and Dental University,
Japan. Title
Suppression by kampo medicines in preneoplastic mammary hyperplastic
alveolar
nodules of SHN virgin mice. Source
Planta Medica. 59(5):425-7, 1993 Oct. Abstract
Sho-saiko-to (SST), Keishi-bukuryo-gan (KBG), and
Shakuyaku-kanzo-to (SKT) are Japanese modified traditional Chinese
herbal
medicines (Kampo medicines) consisting of 7, 5, and 2 medical plants,
respectively. It is known that the hyperplastic alveolar nodule (HAN)
is a
representative preneoplastic state in the mammary glands of mice. We
examined
the effects of SST, KBG, and SKT on the formation and growth of HAN
in a
high-mammary-tumor strain of SHN virgin mice. Oral administration of
SST for
60 days beginning at 90 days of age reduced the number and area of
HAN and
mammary thymidylate synthetase activity with a reduction of serum
prolactin
level. There was little difference between the other experimental
groups and
the control in the formation and growth of HAN and the enzyme
activities.
These results indicate that SST may have a preventive effect on
malignant
mammary transformations. <60> Authors
Yoshida K. Mizukawa H.
Honmura A. Uchiyama Y.
Kaku H. Nakajima S.
Haruki E. Institution
Kanagawa Rehabilitation Institute, Japan. Title
The effect of sho-saiko-to on the concentration of acid
soluble glycoprotein in serum and on granuloma formation in
carrageenin
cotton pellet-induced granuloma rats. Source
American Journal of Chinese Medicine.
21(2):171-7, 1993. Abstract
The effect of sho-saiko-to on the concentration of acid
soluble glycoprotein in serum and on the granuloma formation in
carrageenin
cotton pellet-induced rats was investigated. As a result, a
significant
negative correlation between the concentration of acid soluble
glycoprotein
and granuloma weight was observed. Furthermore, both the
concentration of
acid soluble glycoprotein and the inhibition rate of the granuloma
formation
were significantly higher in the sho-saiko-to group than in
the control group. These results suggest that acid soluble
glycoprotein plays
an important role in promoting the anti-inflammatory effect of
sho-saiko-to. <61> Authors
Sakaguchi S. Tsutsumi E. Yokota
K. Institution
Department of Hygienic Chemistry, Tohoku College of Pharmacy, Sendai,
Japan. Title
Preventive effects of a traditional Chinese medicine
(sho-saiko-to) against oxygen toxicity and membrane damage
during endotoxemia. Source
Biological & Pharmaceutical Bulletin.
16(8):782-6, 1993 Aug. Abstract
The preventive effects of a traditional Chinese medicine
Sho-saiko-to (Kampo prescription, TJ-9) were determined from
oxygen toxicity and membrane damage in liver during endotoxemia. The
liver
lipid peroxide level and xanthine oxidase activity 18 h after
administration
of endotoxin (6 mg/kg, i.p.) to TJ-9 (500 mg/kg/d, p.o.)-pretreated
mice were
markedly lower than that in endotoxin-treated mice, whereas the
administration of TJ-9 significantly increased superoxide dismutase
and
glutathione peroxide activities in liver of endotoxin-injected mice.
In the
mice pretreated with a TJ-9, the levels of alpha-tocopherol and
nonprotein SH
in liver tissue 18 h after endotoxin injection were markedly
increased as
compared to those in endotoxin-treated mice. Leakages of acid
phosphatase and
lactate dehydrogenase isozyme in serum were markedly lower in
endotoxin-TJ-9-treated mice than those in mice given endotoxin. The
administration of TJ-9 clearly prevented the membrane protein damage
arising
from endotoxin challenge. Kampo prescription Sho-saiko-to
thus appears to protect the liver plasma membrane from injury by free
radicals which occur in a tissue ischemic state during endotoxemia. <62> Authors
Tauchi Y. Yamada A.
Kawakita T. Saito Y.
Suzuki A. Yoshikai Y.
Nomoto
K. Institution
Traditional Chinese Medicine Research Laboratories, Kanebo, Ltd.,
Osaka,
Japan. Title
Enhancement of immunoglobulin A production in Peyer's patches by oral
administration of a traditional Chinese medicine, xiao-chai-hu-tang
(Shosaiko-to). Source
Immunopharmacology & Immunotoxicology.
15(2-3):251-72, 1993 Mar-Jun. Abstract
The Peyer's patches contain a large number of precursor cells
committed to
the production of immunoglobulin A (IgA) and play an important role
in IgA
response in the mucosal immune system. We investigated the induction
of IgA
producing cells in Peyer's patches by plaque forming cell assay after
oral
administration of a traditional Chinese herbal medicine,
Xiao-chai-hu-tang
(Japanese name: Shosaiko-to). The number of total IgA
producing cells in the Peyer's patches detected by the protein-A
plaque assay
was increased about two-fold by Shosaiko-to administration
and the numbers of both anti-SRBC and anti-HRBC IgA producing cells
were also
increased by such a treatment. On the other hand, when SRBC alone
were
administered orally, only the number of anti-SRBC IgA producing cells
was
increased. Further, we examined T-cell subpopulations in the
gut-associated
lymphoid tissues after oral administration of Shosaiko-to by
flowcytometry. Marked alternations in T cell subpopulations were not
detected
in the Peyer's patches, though TcR gamma delta+T-cells in the
intraepithelial
lymphocytes and Thy1.2-TcR alpha beta+T cells in the mesenteric lymph
nodes
were slight increased. These results showed that orally administered
Shosaiko-to acts as a polyclonal B-cell activator which
induces IgA production in the mucosal immune system. <63> Authors
Sakamoto S. Mori T.
Sawaki K. Kawachi Y.
Kuwa K. Kudo H.
Suzuki S.
Sugiura Y. Kasahara N.
Nagasawa H. Institution
Medical Research Institute, Tokyo Medical and Dental University,
Japan. Title
Effects of kampo (Japanese herbal) medicine "sho-saiko-to"
on DNA-synthesizing enzyme activity in 1,2-dimethylhydrazine-induced
colonic
carcinomas in rats. Source
Planta Medica. 59(2):152-4, 1993 Apr. Abstract
Sho-Saiko-To (SST) is a modified Japanese traditional
Chinese herbal medicine containing seven medical plants: Bupleuri
radix,
Pinelliae tuber, Suxtallariae radix, Zizyphi fructus, Ginseng radix,
Glycyrrhizae radix, and Zingiberis recens rhizoma. This preparation
has been
used in the treatment of some inflammatory diseases of the
respiratory system
and chronic hepatitis. In the present study, the effects of SST were
investigated on the activities of DNA-synthesizing enzymes in
1,2-dimethylhydrazine (DMH)-induced colonic carcinomas in rats.
Six-week
administration of SST prevented nearly 100% of the body weight loss
and the
final number of the colonic carcinomas compared to those in the rats
treated
with DMH alone, and suppressed the enhanced activities of thymidylate
synthetase (TS) and thymidine kinase (TK) which were involved in the
de novo
and salvage pathways of pyrimidine synthesis, respectively, in DMH-induced colonic carcinomas. These results indicate that SST may show
directly and/or
indirectly inhibitory effects on the development of colonic
carcinomas. <64> Authors
Matsuura K. Kawakita T.
Nakai S. Saito Y.
Suzuki A. Nomoto K. Institution
Traditional Chinese Medicine Research Laboratories, Kanebo Ltd,
Osaka, Japan. Title
Role of B-lymphocytes in the immunopharmacological effects of a
traditional
Chinese medicine, xiao-chai-hu-tang (shosaiko-to). Source
International Journal of Immunopharmacology.
15(2):237-43, 1993 Feb. Abstract
We previously reported that a traditional Chinese medicine,
Xiao-chai-hu-tang
(Japanese name: Shosaiko-to), induced interferon (IFN)
activity in the serum of mice after intraperitoneal (i.p.)
administration. In
the present study in which murine spleen cells were cultured in vitro
with
Shosaiko-to, B-cells isolated by anti-immunoglobulin-coated
plates were confirmed to generate IFN in response to
Shosaiko-to stimulation. IFN activity was induced in the
serum after i.p. administration of Glycyrrhizae radix, Scutellariae
radix,
Bupleuri radix and Pinelliae tuber which are included in
Shosaiko-to as its constituent. Such an IFN-inducing
activity was confirmed to exist in methanol-insoluble fractions of
these
extracts derived from Shosaiko-to and these constituents but
not in methanol-soluble fractions. These four extracts as well as
Shosaiko-to, induced interleukin 6 (IL-6) in the serum after
the administration. In in vitro stimulation of spleen cells,
Shosaiko-to and extracts of Glycyrrhizae radix, Bupleuri
radix and Pinelliae tuber showed mitogenic activity, but an extract
of
Scutellariae radix with in vivo IFN-inducing activity did not.
B-cells appear
to participate in the immunopharmacological effects of
Shosaiko-to through mitogenic activity, IFN induction and
the effect of IL-6. <65> Authors
Okita K. Li Q.
Murakamio T. Takahashi
M. Institution
First Department of Internal Medicine, Yamaguchi University School of
Medicine, Japan. Title
Anti-growth effects with components of Sho-saiko-to (TJ-9)
on cultured human hepatoma cells. Source
European Journal of Cancer Prevention.
2(2):169-75, 1993 Mar. Abstract
The present study was undertaken to investigate the effects and the
mechanism
of the components of Sho-saiko-to (baicalein, baicalin,
saikosaponin-a, saikosaponin-c, ginsenoside Rb1, ginsenoside Rg1) on
cultured
human hepatoma cells (HuH-7). Cell cycle analysis was carried out
with flow
cytometry and the bromodeoxyuridine (BrdU)-labelling method. The
results
showed that baicalein, baicalin and saikosaponin-a inhibited cell
proliferation dose-dependently but independently of the cell cycle.
Furthermore, it was found that saikosaponin-a possesses a strong
cell-killing
effect. On the other hand, saikosaponin-c, ginsenoside Rb1 and
ginsenoside
Rg1 had no effect on cell proliferation. |
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